T cells regulation modulated by Sambucus javanica extracts in DMBA-exposed mice

The protective effect of Sambucus ebulus against lung toxicity induced by gamma irradiation in mice

The aim of present study was to investigate the potential antioxidant and lung protective activities of Sambucus ebulus (SE) against toxicity induced by gamma irradiation. Hydroalcoholic extract of SE (20, 50 and 100 mg/kg) was studied for its lung protective activity. Phenol and flavonoid contents of SE were determined. Male C57 mice were divided into ten groups with five mice per group. Only ...

Effects of T-2 Toxin on Cytokine Produc-tion by Mice Peritoneal Macrophages and Lymph Node T-Cells

Background: T-2 toxin is a mycotoxin of type A trichothecenes produced by several fungal genera such as Fusarium species. Mycotoxins can affect both cell mediated and humoral immune compartments. Objective: The purpose of this study was to investi-gate the effect of T-2 toxin on cytokine production by mouse peritoneal macrophages and lymph node T cells. Methods: Mouse peritoneal macrophages and...

Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells

BXD2 mice spontaneously develop autoantibodies and subsequent glomerulonephritis, offering a useful animal model to study autoimmune lupus. Although initial studies showed a critical contribution of IL-17 and Th17 cells in mediating autoimmune B cell responses in BXD2 mice, the role of follicular helper T (Tfh) cells remains incompletely understood. We found that both the frequency of Th17 cell...

Regulation of immune responses by T cells.

n engl j med 354;11 www.nejm.org march 16, 2006 1166 From the Departments of Medicine (H.J., L.C.) and Pathology and Cell Biology (L.C.), Columbia University College of Physicians and Surgeons, New York. Address reprint requests to Dr. Jiang at the Department of Medicine (Rheumatology), Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, or at hj4@colum...

Immune Regulation by Self-Reactive T Cells